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Assay development & highthroughput screening

Physical
Pricing/Discount Options: Call #2
Unique Identifier: 74c1b45e-1d7a-49db-ab39-17c5efc2c4e6

Service Description

The Unit: Chemical Biology Consortium Sweden (https://www.scilifelab.se/units/cbcs/) The infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science. Chemical Biology Consortium Sweden (CBCS) is a national research infrastructure offering an extensive portfolio of services - from computational and organic chemistry to phenotypic small molecule screens in cells and model organisms, cell painting and functional precision medicine. The mission of CBCS is to provide a state-of-the-art platform and expertise for the generation of high-quality bioactive chemical tools (small organic molecules) for applications within life science research in general and with the ultimate goal to explore complex biology. Our units comprise compound handling labs (hosting the SciLifeLab Compound Collection of ca 350,000 molecules), screening labs (microtiter format liquid handling robotics and a wide range of plate readers), and chemistry labs (equipment and instrumentation for organic chemistry synthesis and analysis).

The service: Assay development & highthroughput screening We provide expertise and technical support in the following areas: o Access to small-molecule compound libraries and robotic instrumentation. o Expertise in assay development and automation. o High-throughput screening: biochemical target-based, cell-based and phenotypic. o High-throughput imaging technology. o Computational chemistry and modelling. o Medicinal chemistry expertise.
o Chemical Biology Platform.

Perspective use case: Purpose The Cell Painting technology can be used to visualize many cellular parameters simultaneously, using organelle-specific fluorescent dyes and high-content imaging. This approach allows you to systematically visualize how cell morphologies react to certain stimuli, like chemical perturbations. It is thus possible to foresee in the near future that the CP technology is a valuable technology to create large systematic AI minable cell morphology resources and customized validation data sets for profiling small molecules and other treatment modalities. Development of new AI software for morphology profiling, cell segmentation for validation sets for functional perturbation assays are needed for future precision medicine. Description of service/ technology: Cell painting, high-content imaging, high-throughput screening Drug library design and delivery, cell culture and immunofluorescence staining Dataset generation, data analysis AI software development Expected outcome: New dataset generation to train AI algorithm on the different type of images generated. Improvement of AI algorithm.

Offerings: Research & Development Scientific & Medical Communication Testing Laboratory (bioanalysis, wet lab, *-omics, etc.)
TEF-Health Use Case Domain: All
Provider Logo Service Logo

Provider & Contact

Provider Organisation Karolinska Institutet (KI)
Provider Country Sweden
Published Email tef-health@ki.se

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Operational Details

Dependencies & Restrictions Facility costs

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